HORDB

ID: hor005460
Uniprot ID: P68987
Protein name: Insulin B chain
Gene name: ins
Organism: Petromyzon marinus (Sea lamprey)
Family: insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Petromyzon (genus), Petromyzontidae (family), Petromyzontiformes (order), Hyperoartia (class), Cyclostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005460_AF2.pdb

hor005460_ESM.pdb

Mass:	434068	Formula:	C165H252N44O50S2
Absent amino acids:	IMNQW	Common amino acids:	G
pI:	7.42	Basic residues:	4
Polar residues:	17	Hydrophobic residues:	12
Hydrophobicity:	28.33	Boman Index:	-1469
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	75.83
Instability Index:	1366.94	Extinction Coefficient cystines:	3105
Absorbance 280nm:	88.71